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• Intracortical MPH increased cortical mobile excitability in rats, an result that was dropped pursuing catecholamine depletion and was mediated via stimulation of α2 adrenergic receptors but not D1 receptors

• AMP inhibited accumulation of DA or NE in rat brain synaptosomes and vesicles, which was mitigated by inhibitors from the DAT and Web

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• Melanin-concentrating hormone form 1 receptor knockout mice exhibited a heightened locomotor reaction to AMP but didn't exhibit altered DA, NE, or five-HT launch within the striatum in reaction to AMP

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In another fMRI analyze in rats, AMP diminished BOLD sign intensity in the nucleus accumbens and prefrontal cortex and amplified signal depth while in the motor cortex of rats, with signal intensity modifications during the nucleus accumbens and caudate (but not in the motor cortex) staying attenuated by pretreatment using a tyrosine-free amino acid mixture (eighty three).

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